Reaction of Steroid-17.ALPHA.-hydroxy-17-carboxylic Acids with Carbodiimides. Synthesis of Steroid-17-spiro-5'-(2'-imino-4'-oxazolidinones) and 17-Spiro-5'-(2',4'-oxazolidinediones).

Synthesis of (4',5'-diaza-9'-fluorene)-spiro-5-hydantoin

Synthesis of (4',5'-diaza-9'-fluorene)-spiro-5-hydantoin: The paper presents a method for synthesis of (4',5'-diaza-9'-fluorene)-spiro-5-hydantoin. The newly obtained compound was synthesized by a treatment of 4,5-diazafluoren-9-one with sodium cyanide, ammonium carbonate, ethanol and ammonium hydroxide at high pressure and high temperature. The structure of (4',5'-diaza-9'-fluorene)-spiro-5-hy...

Cover 17-5 October 2020

5,6-Dimeth­oxy-4′,5′-diphenyl­indane-2-spiro-3′-pyrrolidine-2′-spiro-3′′-indoline-1,2′′-dione

In the title compound, C(33)H(28)N(2)O(4), the central pyrrolidine ring adopts a half-chair conformation. Both the indolinone and indanone groups are twisted, with their five-membered rings adopting a half-chair and an envelope conformation, respectively. The two benzene rings and the mean plane of the indolinone and indanone groups make dihedral angles of 71.98 (10), 84.32 (10), 86.26 (9) and ...

1′-Benzyl-4,4′′-bis­(4-chloro­phen­yl)-3-(2,6-dichloro­phen­yl)-1′′-methyl-4,5-dihydro­isoxazole-5-spiro-3′-piperidine-5′-spiro-3′′-pyrrolidine-2′′-spiro-3′′′-indoline-2′′′,4′-dione

The asymmetric unit of the title compound, C(43)H(34)Cl(4)N(4)O(3), contains two crystallographically independent mol-ecules. In both mol-ecules, the pyrrolidine ring adopts a twist conformation, the oxindole units are slightly distorted from planarity and the isoxazoline ring adopts an envelope conformation. The crystal structure is stabilized by N-H⋯O hydrogen-bonding inter-actions giving one...

Cyclo­hexane-1-spiro-2′-imidazolidine-5′-spiro-1′′-cyclo­hexan-4′-one

In the title compound, C(13)H(22)N(2)O, the central imidazolidine ring is in an envelope conformation and the two cyclo-hexane rings adopt chair conformations. In the crystal structure, the mol-ecules are linked into centrosymmetric R(2) (2)(8) dimers by pairs of N-H⋯O hydrogen bonds.